11/28/2023 0 Comments Graphpad prism 6 heat map![]() ![]() ![]() Hemodynamics were continually monitored and myocardial infarct size determined. Male Sprague-Dawley rats, aged 8–10 weeks, were subjected to an in vivo myocardial ischemia-reperfusion injury protocol involving 30 minutes of ischemia followed by 2 hours of reperfusion. ![]() Therefore, we determined whether morphine-induced cardioprotection is mediated by HSP90 and if the protective effect is downstream of GSK3 β inhibition. HSP90 regulates mitochondrial protein import, with GSK3 β inhibition increasing HSP90 mitochondrial content. In experimental models, this mechanism involves GSK3 β inhibition. Opioids reduce injury from myocardial ischemia-reperfusion in humans.
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